telemetry ecg transmitter eta-f10  (Data Sciences International)

Journal: Scientific Reports

Article Title: Sex- and age-dependent susceptibility to ventricular arrhythmias in the rat heart ex vivo

doi: 10.1038/s41598-024-53803-9

Figure Lengend Snippet: Electrophysiological parameters of ex vivo hearts before and after arrhythmia induction. ( a ) Representative recording of the ECG signal from the surface of the rat heart ex vivo. Heart rate (HR) ( b ), QRS complex duration ( c ), QT interval duration ( d ) and corrected QT interval duration ( e ) in hearts of 3-month-old and 24-month-old male and female rats measured before (basal) and after 20 min of perfusion with isoproterenol (ISO) and hydrogen peroxide (H 2 O 2 ). HR and QRS and QT durations were calculated as the mean values from five consecutive beats. n = 9–10 hearts in each group. *p < 0.05, **p < 0.01, ***p < 0.001. Only statistically significant differences are shown (ISO and H 2 O 2 vs. basal).

Article Snippet: Two platinum electrodes were inserted into the myocardium to a depth of approximately 1 mm, one in the apex and one in the left atrial appendage, and connected to an ECG telemetry transmitter ( Data Sciences International, St. Paul, MN ).

Techniques: Ex Vivo

Journal: bioRxiv

Article Title: Ryanodine receptor inhibition improves cardiac repolarization reserve and contractile function and prevents sudden arrhythmic death in failing hearts

doi: 10.1101/2023.01.29.526151

Figure Lengend Snippet: ( A ) Schematic of experimental design. ( B ) Representative ECG tracings from 24-hour telemetry recordings. Spontaneous incidences of PVCs, VT and VF were suppressed in HF animals with chronic dantrolene treatment. ( C ) Dantrolene therapy lowered PVC burden (p<0.001) in HF animals (blue). ( D ) Kaplan Meier survival plot shows that over 50% of the animals in the vehicle group (HF, N=68, red) group experienced SCD. Chronic dantrolene treatment (HF + DS, N=10, blue) prevented VT and VF in heart failure models and mitigated SCD in 80% of the heart failure animals (p<0.05). A p<0.05 was considered significant; two-tailed log-rank analysis was performed on each group for each measure .

Article Snippet: An ECG transmitter (Data Sciences International ETA-F10 Biopotential Telemetry device) with leads in lead II arrangement and an iPRECIO programmable pump (Primetech Corp., Tokyo, Japan) were implanted in the abdominal cavity.

Techniques: Two Tailed Test

Journal: bioRxiv

Article Title: Ryanodine receptor inhibition improves cardiac repolarization reserve and contractile function and prevents sudden arrhythmic death in failing hearts

doi: 10.1101/2023.01.29.526151

Figure Lengend Snippet: ( A ) Plot shows heart rate derived from 24-hour continuous ECG recordings. The animals were subjected to mild transient β-AR stress for 1 hour. Continuous ECG analysis was performed at the following time points: resting heart rate (pre-stress); transient stress and, post stress recovery (4 hours post stress) ( B ) The box plots summarize HR during the resting and recovery phases. The dantrolene treated group (HF+DS) demonstrate a lower heart rate (HR) both at rest and post-stress recovery. The Δ Heart Rate (bpm) indicates the net increase in HR from resting HR to peak HR in response to transient β-AR stress. Failing hearts displayed higher resting HR and blunted chronotropic response to stress (P<0.02, N≥7 for all models). ( C ) Histogram shows resting HR distribution for all groups. Resting heart rate in decreased in HF+DS animals. However, the peak heart rates (during stress) are higher in HF+DS compared to HF (N; Ctrl=8, HF=10; HF+DS=7). ( D ) Dantrolene increases heart rate variability (HRV) both at rest and during stress (p<0.05, N≥7 for all models). A p<0.05 was considered significant; two-tailed log-rank analysis was performed on each group for each measure .

Article Snippet: An ECG transmitter (Data Sciences International ETA-F10 Biopotential Telemetry device) with leads in lead II arrangement and an iPRECIO programmable pump (Primetech Corp., Tokyo, Japan) were implanted in the abdominal cavity.

Techniques: Derivative Assay, Two Tailed Test

Journal: bioRxiv

Article Title: Ryanodine receptor inhibition improves cardiac repolarization reserve and contractile function and prevents sudden arrhythmic death in failing hearts

doi: 10.1101/2023.01.29.526151

Figure Lengend Snippet: ( A ) Schematic illustrates a randomized 2×2 cross-over experimental design to examine the impact of dantrolene therapy. The protocols were as follows (i) only vehicle administered till the endpoint i.e., week 4 (HF), (ii) dantrolene administered from the onset of HF till until chronic contractile dysfunction is evident in the untreated control HF group (usually 3 weeks post banding; HF+/-DS), or (iii) dantrolene administered after HF had already developed in the HF group (3 weeks post banding; HF-/+DS group). Echocardiography and ECG recordings were taken at week 2/3/4/5. ( B ) Kaplan Meier survival curve showed that 50% of the HF animals experience SCD. Treatment with dantrolene after HF development (around week 3) prevented additional SCDs and improved survival after starting dantrolene therapy in the HFDS-/+ group (purple). Discontinuation of Dantrolene however did not increaser mortality in HF+/-DS group(yellow). ( C ) Serial echocardiography plot shows that Dantrolene reversed heart failure in HF-/+DS (purple) animals. The FS% in this group initially declined at a pace similar to HF (red) animals, but it quickly normalized as soon as Dantrolene therapy was started. However, in the HF+/-DS (yellow) group when the therapy was stopped, the FS% started showing gradual decline, most likely due to washout effect without additional SCD. ( D ) Dantrolene treatment pre or post HF development alters RyR2 oxidation of HF animals (p<0.05). Treatment with dantrolene reduced RyR2 oxidation even when therapy was initiated or discontinued after HF development. ( E ) Close examination of the HF-/+DS (purple) group, pre and post dantrolene therapy shows an increase in PVC load with progression of HF. (G) The box plots summarize QTc pre-HF (light purple), during chronic HF (medium purple) and after dantrolene therapy was initiated (dark purple). The HF-/+DS group displays all symptoms of HF including prolonged QTc after development of HF (around week 3, medium purple box). After start of therapy (dark purple box), QTc shortened at rest and recovery. A p<0.05 was considered significant; two-tailed log-rank analysis was performed on each group for each measure .

Article Snippet: An ECG transmitter (Data Sciences International ETA-F10 Biopotential Telemetry device) with leads in lead II arrangement and an iPRECIO programmable pump (Primetech Corp., Tokyo, Japan) were implanted in the abdominal cavity.

Techniques: Two Tailed Test